{"id":5722,"date":"2021-08-05T03:16:12","date_gmt":"2021-08-04T19:16:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5722"},"modified":"2021-08-05T03:16:12","modified_gmt":"2021-08-04T19:16:12","slug":"extracurricular-laboratory-synthetic-route-of-400755-44-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5722","title":{"rendered":"Extracurricular laboratory: Synthetic route of 400755-44-4"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 400755-44-4, name is 1-Ethylpyrazole-3-carboxylic Acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 400755-44-4, Computed Properties of C6H8N2O2<\/a><\/p>\n

To a solution of 1 -ethyl- 7\/-\/-pyrazole-3-carboxylic acid (1 1 1 mg, 0.793 mmol) and diisopropylethylamine (307 mg, 2.379 mmol) in tetrahydrofuran (4.0 ml_) at 20 C was added 1 -[b\/s(dimethylamino)methylene]- 7\/-\/-1 ,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (452 mg, 1 .19 mmol). The reaction mixture was stirred for 20 minutes before a solution of 5-(3-fluorobenzyl)pyridin-2-amine (160 mg, 0.793 mmol) in tetrahydrofuran (1 .0 ml_) was added. The solution mixture was stirred at 20 C for 16 h. The volatiles were removed under reduced pressure and the residue was added to a mixture of dichloromethane (50 ml_) and water (50 ml_). The combined organic layers were collected, dried over sodium sulfate, filtered and concentrated. The crude sample was dissolved in minimal A\/,A\/-dimethylformamide and purified via prep-HPLC (Boston C18 21 *250 mm 10 pm column; acetonitrile\/0.01 % aqueous trifluoroacetic acid) to give 1 -ethyl-A\/-(5-(3-fluorobenzyl)pyridin-2-yl)- 7\/-\/-pyrazole-3-carboxamide (43.0 mg, 0.132 mmol, 16.7%) as a white solid. 1 H NMR (400 MHz, Dimethylsulfoxide-c\/6) d 9.51 (s, 1 H), 8.27 (d, J = 2.0 Hz, 1 H), 8.08 (d, J = 8.5 Hz, 1 H), 7.92 (d, J = 2.3 Hz, 1 H), 7.71 – 7.70 (dd, J = 8.5, 2.2 Hz, 1 H), 7.33 – 7.30 (dd, J = 14.3, 8.0 Hz, 1 H), 7.10 – 7.08 (t, J = 7.0 Hz, 2H), 7.02 – 7.01 (dd, J = 1 1 .9, 5.3 Hz, 1 H), 6.82 (d, J = 2.3 Hz, 1 H), 4.23 – 4.21 (q, J = 7.3 Hz, 2H), 3.95 (s, 2H), 1 .41 – 1 .40 (t, J = 7.3 Hz, 3H).; LCMS (ESI) m\/z: 325.1 [M+H]+.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Ethylpyrazole-3-carboxylic Acid, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; YUMANITY THERAPEUTICS, INC.; LE BOURDONNEC, Bertrand; LUCAS, Matthew; OZBOYA, Kerem; PANDYA, Bhaumik; TARDIFF, Daniel; TIVITMAHAISOON, Parcharee; WRONA, Iwona; (475 pag.)WO2019\/183587; (2019); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Ethylpyrazole-3-carboxylic Acid, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[540,131],"tags":[126],"class_list":["post-5722","post","type-post","status-publish","format-standard","hentry","category-400755-44-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 400755-44-4, name is 1-Ethylpyrazole-3-carboxylic Acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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