{"id":5713,"date":"2021-08-04T03:11:12","date_gmt":"2021-08-03T19:11:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5713"},"modified":"2021-08-04T03:11:12","modified_gmt":"2021-08-03T19:11:12","slug":"analyzing-the-synthesis-route-of-5334-40-7-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5713","title":{"rendered":"Analyzing the synthesis route of 5334-40-7"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H3N3O4<\/a><\/p>\n

Thionyl chloride (6.28ml_, 86.07mmol) was added to an ice cooled solution of 4-nitro-1 H- pyrazole-3-carboxylic acid (10.4 g, 66.21 mmol) in methanol (150 ml_). The resulting solution was stirred at RT O\/N. The day after MeOH was removed under vacuum; toluene was added and dried again. The solid was suspended in pentane and filtered under vacuum to afford methyl 4-nitro-1 H-pyrazole-3-carboxylate (p128, 1 1 .15 g, y= 98%) as creamy solid. MS (mlz): 171 .9 [MH]+<\/p>\n

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; CHRONOS THERAPEUTICS LIMITED; MICHELI, Fabrizio; BERTANI, Barbara; GIBSON, Karl Richard; DI FABIO, Romano; RAVEGLIA, Luca; ZANALETTI, Riccardo; CREMONESI, Susanna; POZZAN, Alfonso; SEMERARO, Teresa; TARSI, Luca; LUKER, Timothy Jon; (275 pag.)WO2019\/43407; (2019); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[153,131],"tags":[126],"class_list":["post-5713","post","type-post","status-publish","format-standard","hentry","category-5334-40-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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