{"id":5712,"date":"2021-08-04T03:11:12","date_gmt":"2021-08-03T19:11:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5712"},"modified":"2021-08-04T03:11:12","modified_gmt":"2021-08-03T19:11:12","slug":"continuously-updated-synthesis-method-about-c3h5n3o","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5712","title":{"rendered":"Continuously updated synthesis method about C3H5N3O"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/28491-52-3.html\">Electric Literature of 28491-52-3<\/a>,Some common heterocyclic compound, 28491-52-3, name is 5-Amino-1H-pyrazol-3(2H)-one, molecular formula is C3H5N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n<p>5-Amino-2,3-dihydro-1 H-pyrazol-3-one is dissolved in aqueous EtOH containing KOH. To this solution is added methyl 3-(3-trifluoromethyl-phenyl)-3-oxopropanoate and the mixture is stirred under reflux for 1 h 30 min. After cooling to rt, water is added and the mixture is acidified by addition of acetic acid to pH~5. The resulting precipitate is collected on a filter, washed with water and diethyl ether, and dried to give the title compound in moderate yield. Mp >;250 0C (decomp.); 1H-NMR (200 MHz, DMSO-d6), delta (ppm) 5.46 (s, 1 H); 6.05 (s, 1 H); 7.75 (t, 4 Hz, 1 H); 7.89 (d, 4 Hz, 2H); 8.07-8.12 (m, 1 H); 10.90 (br s, 1 H) and 12.25 (br s, 1 H). LC-MS m\/z 296 (M+1 )<\/p>\n<p>These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1H-pyrazol-3(2H)-one, its application will become more common.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2010139483&#038;F=0\">Patent; MERZ PHARMA GMBH &amp;; CO. KGAA; HENRICH, Markus; BAUER, Angela; KRUeGER, Bjoern; KAUSS, Valerjans; MUeLLER, Sibylle; KUBAS, Holger; ROZHKOVS, Jevgenijs; PISKUNOVA, Irene; WO2010\/139483; (2010); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1H-pyrazol-3(2H)-one, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[243,131],"tags":[145],"class_list":["post-5712","post","type-post","status-publish","format-standard","hentry","category-28491-52-3","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Continuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Electric Literature of 28491-52-3,Some common heterocyclic compound, 28491-52-3, name is 5-Amino-1H-pyrazol-3(2H)-one, molecular formula is C3H5N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5712\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Continuously updated synthesis method about\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 28491-52-3,Some common heterocyclic compound, 28491-52-3, name is 5-Amino-1H-pyrazol-3(2H)-one, molecular formula is C3H5N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5712\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-03T19:11:12+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5712\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5712\",\"name\":\"Continuously updated synthesis method about\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-08-03T19:11:12+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Electric Literature of 28491-52-3,Some common heterocyclic compound, 28491-52-3, name is 5-Amino-1H-pyrazol-3(2H)-one, molecular formula is C3H5N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5712#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=5712\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5712#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Continuously updated synthesis method about C3H5N3O\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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