{"id":5709,"date":"2021-08-04T03:11:12","date_gmt":"2021-08-03T19:11:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5709"},"modified":"2021-08-04T03:11:12","modified_gmt":"2021-08-03T19:11:12","slug":"the-important-role-of-288-13-1-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5709","title":{"rendered":"The important role of 288-13-1"},"content":{"rendered":"

Reference of 288-13-1<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-13-1, name is 1H-Pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

1-isopropyl-1H-pyrazole : To a solution of pyrazole (50.0 g, 735.3 mmol) in aqueous sodium hydroxide (123.5 g NaOH\/200 ml of water), was added isopropyl bromide (180.0 g, 1470.1 mmol) and the mixture was then heated to reflux for 6-7 days. The reaction mixture was cooled and extracted with ethyl acetate (3 x 300 ml). The combined organic layers were dried over MgS04<\/sub. Removal of the volatiles in vacuo provided a light yellow oil, which was distilled via Kugelrohr at 140C and 10 Torr, to provide 1-isopropyl-1H-pyrazole as a colorless oil (43 g, 53%). LCMS mlz (%) =111 M+H+ , (100). 1H NMR (400 MHz, DMSO-d6<\/sub>) delta: 7.72 (d, J= 2.3 Hz, 1H), 7.41 (t, 1H), 6.21 (t, 1H), 4.5 (q, 1H), 1.41-1.37 (d, J= 11.1 Hz).<\/p>\n

The synthetic route of 1H-Pyrazole has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2005\/12254; (2005); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1H-Pyrazole has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[149,131],"tags":[145],"class_list":["post-5709","post","type-post","status-publish","format-standard","hentry","category-288-13-1","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Reference of 288-13-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-13-1, name is 1H-Pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5709\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of\" \/>\n<meta property=\"og:description\" content=\"Reference of 288-13-1, In the next few decades, the world population will flourish. 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