{"id":5708,"date":"2021-08-04T03:11:12","date_gmt":"2021-08-03T19:11:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5708"},"modified":"2021-08-04T03:11:12","modified_gmt":"2021-08-03T19:11:12","slug":"simple-exploration-of-5932-34-3-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5708","title":{"rendered":"Simple exploration of 5932-34-3"},"content":{"rendered":"

Synthetic Route of 5932-34-3<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5932-34-3, name is Ethyl 4-bromo-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

To a microwave vial was added isopropyl alcohol (10 mL), ethyl 4-bromo-1H-pyrazole-3-carboxylate (from ChemBridge) (788 mg, 3.60 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (48.9 muL, 0.327 mmol) and 4-[3-(cyanomethylene)azetidin-1-yl]-2,5-difluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzamide (from Example 4 step 4, 1.13 g, 3.27 mmol). The reaction mixture was stirred at 80 C. for 2 h. After cooling to room temperature, the solvent was removed in vacuo. The residue was purified with flash chromatography (eluting with 0-35% ethyl acetate in hexanes) to give the desired product as white foam. 1H NMR (500 MHz, DMSO) delta 8.61 (s, 1H), 8.47 (d, J=8.7 Hz, 1H), 7.34 (dd, J=12.5 and 6.3 Hz, 1H), 6.62 (dd, J=11.9 and 7.3 Hz, 1H), 4.76 (dt, J=15.5 and 7.8 Hz, 1H), 4.61 (d, J=9.2 Hz, 2H), 4.39 (d, J=8.0 Hz, 2H), 4.32 (q, J=7.1 Hz, 2H), 3.68 (s, 2H), 1.31 (m, 6H) ppm. LCMS calculated for C21H20BrF5N5O3 (M+H)+: m\/z=564.1. Found: 563.8.<\/p>\n

The synthetic route of Ethyl 4-bromo-1H-pyrazole-3-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Incyte Corporation; Li, Yun-Long; Zhuo, Jincong; Qian, Ding-Quan; Mei, Song; Cao, Ganfeng; Pan, Yongchun; Li, Qun; Jia, Zhongjiang; US2014\/343030; (2014); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of Ethyl 4-bromo-1H-pyrazole-3-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[381,131],"tags":[127],"class_list":["post-5708","post","type-post","status-publish","format-standard","hentry","category-5932-34-3","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 5932-34-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5932-34-3, name is Ethyl 4-bromo-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5708\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Simple exploration of\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 5932-34-3, In the next few decades, the world population will flourish. 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