{"id":5673,"date":"2021-08-03T03:22:49","date_gmt":"2021-08-02T19:22:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5673"},"modified":"2021-08-03T03:22:49","modified_gmt":"2021-08-02T19:22:49","slug":"simple-exploration-of-127107-23-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5673","title":{"rendered":"Simple exploration of 127107-23-7"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 127107-23-7 as follows. Quality Control of 1-Methyl-1H-pyrazol-4-amine hydrochloride<\/a><\/p>\n

6-((2,5-dichloropyrimidin-4-yl)(methyl)amino)hexahydrofuro[3,2-b]furan-3-ol (342.2mg, 1.12 mmol) and 1-methyl-1H-pyrazol-4-amine hydrochloride (185.0 mg,1.38 mmol) was suspended in n-BuOH (5 mL) and DIPEA (358.8 mg, 2.78 mmol) was added. The resulting reaction was warmed to 150 C and the sealed tube was allowed to react overnight. The reaction mixture was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (DCM \/ MeOH (v \/ v) = 40\/1) to give the title compound as a beige solid (156 mg, 38.0%).<\/p>\n

According to the analysis of related databases, 127107-23-7, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Li Xiaobo; Dai Weilong; Wang Tingjin; (74 pag.)CN104926824; (2017); B;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 127107-23-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298,131],"tags":[126],"class_list":["post-5673","post","type-post","status-publish","format-standard","hentry","category-127107-23-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 127107-23-7 as follows. 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