{"id":5670,"date":"2021-08-02T03:24:45","date_gmt":"2021-08-01T19:24:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5670"},"modified":"2021-08-02T03:24:45","modified_gmt":"2021-08-01T19:24:45","slug":"sources-of-common-compounds-2817-71-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5670","title":{"rendered":"Sources of common compounds: 2817-71-2"},"content":{"rendered":"<p>Some common heterocyclic compound, 2817-71-2, name is 1-Ethylpyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. <a href=\"https:\/\/www.ambeed.com\/products\/2817-71-2.html\">name: 1-Ethylpyrazole<\/a><\/p>\n<p>General procedure: In athree-necked bottle, 0.82 g (10 mmol)1-methylpyrazole and 1.25 g(10mmol) bromoethanolwere added into 10mL CH3CN. Then, themixtureswere stirred at reflux temperature for 48 h in a nitrogen atmosphere.After the reaction, the volatiles were removed under reducedpressure. The residual was washed several times by ethyl acetate togive a white solid. After filtration and drying in vacuum, the pureHEMPzBr was obtained: 1.532 g, yield 74%, white solid. 1H NMR(400 MHz, DMSO-d6) delta 8.58 (dd, J = 21.9, 2.8 Hz, 2H, Pz-H), 6.86 (t, J = 3.1 Hz, 1H, Pz-H), 5.26 (s, 1H, -OH), 4.61 (t, J = 5.0 Hz, 2H, -CH2-),4.20 (s, 3H, -CH3), 3.76 (t, J = 5.2 Hz, 2H, -CH2-).13C NMR (101 MHz,D2O) delta 138.38, 137.98, 107.43, 59.34, 52.34, 37.61. HR-MS (QTOF)calcd. for [C6H11N2O+] (m\/z): 127.0866, found: 127.0868.<\/p>\n<p>These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2817-71-2, its application will become more common.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.molliq.2019.111479\">Article; Wang, Tengfei; Ma, Yuan; Jiang, Jiamin; Zhu, Xinrui; Fan, Baowan; Yu, Guanyao; Li, Ningning; Wang, Shasha; Ren, Tiegang; Wang, Li; Zhang, Jinglai; Journal of Molecular Liquids; vol. 293; (2019);<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2817-71-2, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[534,131],"tags":[145],"class_list":["post-5670","post","type-post","status-publish","format-standard","hentry","category-2817-71-2","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Sources of common compounds:<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 2817-71-2, name is 1-Ethylpyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Ethylpyrazole\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5670\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds:\" \/>\n<meta property=\"og:description\" content=\"Some common heterocyclic compound, 2817-71-2, name is 1-Ethylpyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Ethylpyrazole\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5670\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-01T19:24:45+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5670\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5670\",\"name\":\"Sources of common compounds:\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-08-01T19:24:45+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Some common heterocyclic compound, 2817-71-2, name is 1-Ethylpyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Ethylpyrazole\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5670#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=5670\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5670#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Sources of common compounds: 2817-71-2\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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