{"id":5665,"date":"2021-08-02T03:24:45","date_gmt":"2021-08-01T19:24:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5665"},"modified":"2021-08-02T03:24:45","modified_gmt":"2021-08-01T19:24:45","slug":"a-new-synthetic-route-of-c5h7brn2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5665","title":{"rendered":"A new synthetic route of C5H7BrN2"},"content":{"rendered":"<p>Adding a certain compound to certain chemical reactions, such as: 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound  3398-16-1, <a href=\"https:\/\/www.ambeed.com\/products\/3398-16-1.html\">Product Details of 3398-16-1<\/a><\/p>\n<p>General procedure: 4.4.1. Ethyl 5-amino-2-phenylpyrazolo[1,5-a]quinoline-3-carboxylate (13aa). A mixture of 2-fluorobenzonitrile 6a (121 mg,1.00 mmol), 12a (280 mg, 1.20 mmol) and Cs2CO3 (980 mg,3.00 mmol) in DMSO (5.0 mL) was stirred at 120 C for 16 h. Aftermonitoring the end of the reaction on TLC, the mixture was cooledto room temperature and diluted with water. The resulting mixturewas extracted with ethyl acetate twice. The combined organiclayers were washed with water twice, dried over MgSO4 and thesolvent was removed in vacuo to afford a residue. The residue waspurified by flash column chromatography (hexane:EtOAc1:1) onsilica gel to afford pyrazolo[1,5-a]quinoline 13aa (137 mg, 41percentyield).<\/p>\n<p>In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3,5-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tet.2014.02.081\">Article; Kato, Jun-Ya; Ijuin, Ryosuke; Aoyama, Hiroshi; Yokomatsu, Tsutomu; Tetrahedron; vol. 70; 17; (2014); p. 2766 &#8211; 2775;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3,5-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[250,131],"tags":[126],"class_list":["post-5665","post","type-post","status-publish","format-standard","hentry","category-3398-16-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A new synthetic route of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new synthetic route of","description":"Adding a certain compound to certain chemical reactions, such as: 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3398-16-1, Product Details of 3398-16-1","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=5665","og_locale":"en_US","og_type":"article","og_title":"A new synthetic route of","og_description":"Adding a certain compound to certain chemical reactions, such as: 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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