{"id":5664,"date":"2021-08-02T03:24:45","date_gmt":"2021-08-01T19:24:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5664"},"modified":"2021-08-02T03:24:45","modified_gmt":"2021-08-01T19:24:45","slug":"introduction-of-a-new-synthetic-route-about-5775-86-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5664","title":{"rendered":"Introduction of a new synthetic route about 5775-86-0"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 5775-86-0, name is 4-Bromo-1,5-dimethylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5775-86-0, Safety of 4-Bromo-1,5-dimethylpyrazole<\/a><\/p>\n

To a solution of 1.5 (lg, 3.22mmol, leq) in 1,4- dioxane (7 .2mL) and water (2. 8mL) was added 4-bromo- 1,5 -dimethyl- 1 H-pyrazole (0. 780g, 4.83mmol,1.5eq),and potassium carbonate (1.27g, 9.67mmol, 3eq).The reaction mixture was degassed by argon for 30 mm. [1,1 ?-Bi sdiphenylphosphinoferrocene]palladium(II) dichloride CH2C12 complex (0.080g, 9.67mmol, 0.O3eq), was added into reaction mixture and again reaction mixture was degassed by argon for 30 mm. Further reaction mixture was stirred at 100C for 4h. Upon completion, reaction mixture transferred into water and extracted with ethyl acetate. Organic layers were combined, dried over Na2SO4 and concentrated in vacuo to obtain crude product. This was purified by column chromatography and compound was eluted in 20% ethyl acetate in hexane to obtain pure 631.6 (0.530g, 59.06%). MS(ES): m\/z 279.37 [M+H]t<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1,5-dimethylpyrazole, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (869 pag.)WO2018\/75937; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1,5-dimethylpyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[543,131],"tags":[126],"class_list":["post-5664","post","type-post","status-publish","format-standard","hentry","category-5775-86-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 5775-86-0, name is 4-Bromo-1,5-dimethylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5775-86-0, Safety of 4-Bromo-1,5-dimethylpyrazole\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5664\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Introduction of a new synthetic route about\" \/>\n<meta property=\"og:description\" content=\"Adding a certain compound to certain chemical reactions, such as: 5775-86-0, name is 4-Bromo-1,5-dimethylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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