{"id":5643,"date":"2021-07-31T03:27:26","date_gmt":"2021-07-30T19:27:26","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5643"},"modified":"2021-07-31T03:27:26","modified_gmt":"2021-07-30T19:27:26","slug":"simple-exploration-of-23170-45-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5643","title":{"rendered":"Simple exploration of 23170-45-8"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23170-45-8, Formula: C6H8N2O2<\/a><\/p>\n

N2 protection,Methyl-1H-pyrazole-4-carboxylate (0.14 g, 1.0 mmol), CuI (19.1 mg, 0.1 mmol), K2CO3 (0.29 g, 2.1 mmol)III1 (0.318 g, 1.2 mmol),(E) -N, N’-dimethyl-1,2-cyclohexyl diamine (28.5 mg, 0.2 mmol) and DMF (3 mL) were added to a 25 mL two-necked flask and reacted at 110 C for 24 h,Cooled to room temperature, diluted with 10 mL of water, extracted with ethyl acetate (15 mL x 3)Saturated brine (10 mL), dried over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure,Silica gel column (V ethyl acetate: V petroleum ether = 6: 1),0.15 g of methyl 4- (3′-cyano-4′-piperidine-phenyl) -3-methyl-pyrazole-4-carboxylate (IV1) as a yellow solid in a yield of 46.2%.<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-methyl-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; South China University of Technology; Zhang Lei; Wu Fangping; Li Jing; Zou Yake; (15 pag.)CN106632245; (2017); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-methyl-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[397,131],"tags":[126],"class_list":["post-5643","post","type-post","status-publish","format-standard","hentry","category-23170-45-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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