{"id":5613,"date":"2021-07-30T06:06:27","date_gmt":"2021-07-29T22:06:27","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5613"},"modified":"2021-07-30T06:06:27","modified_gmt":"2021-07-29T22:06:27","slug":"continuously-updated-synthesis-method-about-15-dimethyl-1h-pyrazole-3-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5613","title":{"rendered":"Continuously updated synthesis method about 1,5-Dimethyl-1H-pyrazole-3-carboxylic acid"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5744-59-2 as follows. Formula: C6H8N2O2<\/a><\/p>\n

Example 85 Production of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,5-dimethyl-1H-pyrazole-3-carboxamide In the same manner as in Example 259 and using 1,5-dimethyl-1H-pyrazole-3-carboxylic acid (145 mg, 1.0 mmol), tetrahydrofuran (5 mL), N,N-dimethylformamide (1 drop), oxalyl chloride (320 muL, 4.44 mmol), N-[6-(3-amino-4-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (250 mg, 0.77 mmol) and N,N-dimethylacetamide (7 mL) as starting materials, the title compound (57 mg, 17%) was obtained as a white solid. 1H-NMR (DMSO-d6, 300 MHz) delta 0.76-0.86 (4H, m), 1.87-1.97 (1H, m), 2.27 (3H, s), 2.30 (3H, s), 3.83 (3H, s), 6.53 (1H, s), 6.97-7.06 (2H, m), 7.25-7.34 (1H, m), 7.61 (1H, d, J=2.3 Hz), 7.92-7.97 (1H, m), 8.02 (1H, d, J=9.5 Hz), 9.35 (1H, s), 11.07 (1H, s).<\/p>\n

According to the analysis of related databases, 5744-59-2, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009\/137595; (2009); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 5744-59-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[206,131],"tags":[126],"class_list":["post-5613","post","type-post","status-publish","format-standard","hentry","category-5744-59-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5744-59-2 as follows. 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