{"id":5605,"date":"2021-07-29T08:16:22","date_gmt":"2021-07-29T00:16:22","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5605"},"modified":"2021-07-29T08:16:22","modified_gmt":"2021-07-29T00:16:22","slug":"new-downstream-synthetic-route-of-694-31-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5605","title":{"rendered":"New downstream synthetic route of 694-31-5"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 694-31-5 as follows. Quality Control of 1,5-Dimethyl-1H-pyrazole<\/a><\/p>\n

N-Iodosuccinimide (35.8 g, 159 mmol) was added to a 10 C. solution of 1,5-dimethyl-1H-pyrazole (15.3 g, 159 mmol) in N,N-dimethylformamide (20 mL). The reaction mixture was stirred at 10 C. for 16 hours, and at 15 C. for 48 hours, whereupon it was diluted with ethyl acetate (500 mL) and washed sequentially with water (3*100 mL), aqueous sodium sulfite solution (100 mL), and saturated aqueous sodium chloride solution (50 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to afford the product as a white solid. Yield: 28.0 g, 126 mmol, 79%. 1H NMR (400 MHz, CDCl3) delta 7.41 (s, 1H), 3.85 (s, 3H), 2.29 (s, 3H).<\/p>\n

According to the analysis of related databases, 694-31-5, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; Pfizer Inc.; Kablaoui, Natasha Mariam; Green, Michael Eric; Montgomery, Justin Ian; Brodney, Michael Aaron; Verhoest, Patrick Robert; Kauffman, Gregory Wayne; Rankic, Danica Antonia; Mente, Scot Richard; Rogers, Bruce Nelsen; Arora, Kapildev Kashmirilal; Dunn, Matthew Francis; (98 pag.)US2018\/148432; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 694-31-5, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[514,131],"tags":[145],"class_list":["post-5605","post","type-post","status-publish","format-standard","hentry","category-694-31-5","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nNew downstream synthetic route of<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 694-31-5 as follows. 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