{"id":5604,"date":"2021-07-29T08:16:22","date_gmt":"2021-07-29T00:16:22","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5604"},"modified":"2021-07-29T08:16:22","modified_gmt":"2021-07-29T00:16:22","slug":"the-important-role-of-5334-39-4-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5604","title":{"rendered":"The important role of 5334-39-4"},"content":{"rendered":"

Synthetic Route of 5334-39-4<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5334-39-4 as follows.<\/p>\n

To a stirred solution of 3-methyl-4-nitro-lH-pyrazole (1.24 g, 0.009 mol, 1 equiv) in DMF (20 mL) was added K2CO3 (1.86 g, 0.013 mol, 1 equiv) portion wise at 0C and stirred for 10 minutes. l-(bromomethyl)-2,4-bis(trifluoromethyl)benzene (3 gm, 0.009 mol, 1 equiv) was added drop wise 0C. The reaction mixture was allowed to stir for 1 hour at RT. Product formation was confirmed by LCMS. After completion of reaction, reaction mixture was diluted with water and extracted with ethyl acetate (100 mL x 3). Combined organic extracts were washed with water (100 mL x 4), dried over anhydrous Na2S04 and concentrated under reduced pressure to obtain mixture of l-(2,4-bis(trifluoromethyl)benzyl)- 3-methyl-4-nitro-lH-pyrazole(peak 1) and l-(2,4-bis(trifluoromethyl)benzyl)-5-methyl-4- nitro-lH-pyrazole(peak 2). obtained crude was sent for separation in prep. LCMS: 353 [M+H] +.<\/p>\n

According to the analysis of related databases, 5334-39-4, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; PRAXIS BIOTECH LLC; ALFARO, Jennifer; BELMAR, Sebastian; NUNEZ VASQUEZ, Gonzalo Esteban; PUJALA, Brahmam; SATHE, Balaji Dashrath; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; THAKRAL, Pooja; PATIDAR, Rajesh Kumar; (344 pag.)WO2019\/195810; (2019); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 5334-39-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[216,131],"tags":[126],"class_list":["post-5604","post","type-post","status-publish","format-standard","hentry","category-5334-39-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 5334-39-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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