{"id":5582,"date":"2021-07-28T05:54:35","date_gmt":"2021-07-27T21:54:35","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5582"},"modified":"2021-07-28T05:54:35","modified_gmt":"2021-07-27T21:54:35","slug":"continuously-updated-synthesis-method-about-3-iodo-1-methyl-1h-pyrazole-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5582","title":{"rendered":"Continuously updated synthesis method about 3-Iodo-1-methyl-1H-pyrazole"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-Iodo-1-methyl-1H-pyrazole<\/a><\/p>\n

Step 1. Synthesis of 5-fluoro-3-iodo-1-methyl-1H-pyrazole (C27) Lithium diisopropylamide (2.0 M in heptane\/tetrahydrofuran\/ethylbenzene, 3.30 mL, 6.60 mmol) was added drop-wise to a -75 C. solution of 3-iodo-1-methyl-1H-pyrazole (97%, 1.29 g, 6.02 mmol) in tetrahydrofuran (25 mL). After 5 minutes, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide (97%, 2.60 g, 8.00 mmol) was added to the cold solution in one portion. The reaction mixture was allowed to warm to 0 C. over 30 minutes, and was then quenched with saturated aqueous ammonium chloride solution (25 mL) and extracted with ethyl acetate (3*30 mL). The combined organic layers were washed with saturated aqueous sodium chloride solution (15 mL), dried over sodium sulfate, filtered, and concentrated in vacuo. Purification via silica gel chromatography (Gradient: 0% to 50% ethyl acetate in heptane) afforded the product as a pale yellow oil. Yield: 435 mg, 1.92 mmol, 32%. GCMS m\/z 226 [M+]. 1H NMR (400 MHz, CDCl3) delta 5.93 (d, J=6.0 Hz, 1H), 3.74 (d, J=1.2 Hz, 3H).<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 92525-10-5.<\/p>\n

Reference:
Patent; Pfizer Inc.; Brodney, Michael Aaron; Butler, Christopher Ryan; Beck, Elizabeth Mary; Davoren, Jennifer Elizabeth; LaChapelle, Erik Alphie; O’Neill, Brian Thomas; US2014\/228356; (2014); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 92525-10-5.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[172,131],"tags":[127],"class_list":["post-5582","post","type-post","status-publish","format-standard","hentry","category-92525-10-5","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-Iodo-1-methyl-1H-pyrazole\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5582\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Continuously updated synthesis method about\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, This compound has unique chemical properties. 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