{"id":5539,"date":"2021-07-27T03:19:32","date_gmt":"2021-07-26T19:19:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5539"},"modified":"2021-07-27T03:19:32","modified_gmt":"2021-07-26T19:19:32","slug":"some-tips-on-2-4-nitro-1h-pyrazol-1-ylethanol","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5539","title":{"rendered":"Some tips on 2-(4-Nitro-1H-pyrazol-1-yl)ethanol"},"content":{"rendered":"<p>42027-81-6, name is 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. <a href=\"https:\/\/www.ambeed.com\/products\/42027-81-6.html\">Formula: C5H7N3O3<\/a><\/p>\n<p>Palladium 10% on carbon (0.2 g) was added to a solution of compound 20-c (1.1 g, 7 mmol) in ethanol (20 mL) under hydrogen gas atmosphere (1 atm). The mixture was reacted at 25 C. for 16 hours, filtered and the filtrate was concentrated under reduced pressure to give 20-b as a red oil (740 mg, yield 83%), which was directly used for the next step without purification. LC-MS (ESI): m\/z=128[M+H]+.<\/p>\n<p>The synthetic route of 42027-81-6 has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2016042341&#038;F=0\">Patent; GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.; XU, Zusheng; ZHANG, Nong; WANG, Tinghan; SUN, Qingrui; WANG, Yuguang; (90 pag.)US2018\/208604; (2018); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 42027-81-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[276,131],"tags":[126],"class_list":["post-5539","post","type-post","status-publish","format-standard","hentry","category-42027-81-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Some tips on<\/title>\n<meta name=\"description\" content=\"42027-81-6, name is 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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