{"id":5529,"date":"2021-07-27T03:19:32","date_gmt":"2021-07-26T19:19:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5529"},"modified":"2021-07-27T03:19:32","modified_gmt":"2021-07-26T19:19:32","slug":"extended-knowledge-of-39806-90-1-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5529","title":{"rendered":"Extended knowledge of 39806-90-1"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39806-90-1, Safety of 4-Iodo-1-methyl-1H-pyrazole<\/a><\/p>\n

EXAMPLE 7; rac-3 -[(\/ ?,2J?)-2-Hydroxycyclohexyl] -6- { [4-( 1 -methyLiH-pyrazol-4-yl)-3-oxopiperazin- 1 – yl] methyl } benzo [h] quinazolin-4(JH)-oneSynthesis of l-(l-methyl-7H-pyrazol-4-yl)piperazin-2-one.To a solution of \/eri-bulyl 3-oxopiperazine-l-carboxylate (0.164 g, 0,819 mmol) in 3 mL of isopropanol under an atmosphere of nitrogen was added l-methyI-4-iodo-\/H-pyrazole (0.204 g, 0.983 mmol), ethylene glycol (0.051 g, 0.82 mmol), copper iodide (0.031 g, 0.16 mmol), and potassium phosphate (0.695 g, 3.28 mmol). The reaction was heated to 100C for 8 h; cooled to rt, and concentrated in vacuo. The residue was dissolved in dichloromethane, washed with water, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified via silica gel chromatography, eluting with 10-100% ethyl acetate in hexanes to provide tert- butyl 4-(l-methyl-7H-pyrazol-4-yl)-3-oxopiperazine-l-carboxylate that gave a mass ion (ES+) of 281.1 for [M+H .<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; BESHORE, Douglas, C.; DIMARCO, Christina, Ng; GRESHOCK, Thomas, J.; WO2011\/84371; (2011); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[162,131],"tags":[127],"class_list":["post-5529","post","type-post","status-publish","format-standard","hentry","category-39806-90-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nExtended knowledge of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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