{"id":5524,"date":"2021-07-27T03:19:32","date_gmt":"2021-07-26T19:19:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5524"},"modified":"2021-07-27T03:19:32","modified_gmt":"2021-07-26T19:19:32","slug":"simple-exploration-of-1904-31-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5524","title":{"rendered":"Simple exploration of 1904-31-0"},"content":{"rendered":"

Electric Literature of 1904-31-0<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1904-31-0 as follows.<\/p>\n

To a suspension of 6-((6-bromo-1 H-[1 ,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline (68 mg, 0.2 mmol) (prepared from quinolin-6-ylmethanamine following the procedures of Compound 1 ) and 1-methyl-1 H-pyrazol-3-amine (20 mg, 0.22 mmol) in dioxane (5ml_) were added Cs2C03 (72 mg, 0.22 mmol) and H20 (0.5 ml_). The mixture was degassed and charged with N2 three times, then Pd2(dba)3 (0.02 mmol, 18 mg) and xantphos (0.04 mmol, 23 mg) were added. The resulting mixture was stirred at 120\u00b0C under one atmosphere of N2 overnight, then concentrated. The resulting residue was purified by chromatography to afford the title compound (10 mg). MS (m\/z): 358 (M-M f.<\/p>\n

According to the analysis of related databases, 1904-31-0, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu; WO2011\/79804; (2011); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 1904-31-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[219,131],"tags":[145],"class_list":["post-5524","post","type-post","status-publish","format-standard","hentry","category-1904-31-0","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Electric Literature of 1904-31-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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