{"id":5519,"date":"2021-07-23T03:40:41","date_gmt":"2021-07-22T19:40:41","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5519"},"modified":"2021-07-23T03:40:41","modified_gmt":"2021-07-22T19:40:41","slug":"analyzing-the-synthesis-route-of-113100-53-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5519","title":{"rendered":"Analyzing the synthesis route of 113100-53-1"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 113100-53-1 as follows. Computed Properties of C6H5F3N2O2<\/a><\/p>\n

EXAMPLE 1 This Example illustrates the preparation of 1-methyl-3-trifluoromethyl-1 H-pyrazole-4- carboxylic acid (theta-dichloromethylidene-benzonorbornene-S-yOamide (compound A-1.4):theta-Dichloromethylene-S-amino-benzonorbomene (175 mg, 0.729 mmol, prepared as described in Example 6) in dichloromethane (10ml) was reacted with 1-methyl-3- trifluoromethyl-1 H-pyrazole-carboxylic acid (170mg, 0.874 mmol, 1.2 eq.) in the presence of bis-(2-oxo-3-oxazolidinyl)-phosphinic acid chloride (278 mg, 1.09 mmol, 1.5 eq.) and triethylamine (184 mg, 1.821 mmol, 2.5 eq.) at ambient temperature under stirring for 23 hours. The reaction mixture was extracted with saturated sodium bicarbonate solution and saturated brine, dried over Na2SO4 and purified on silica gel in ethyl acetate-hexane-(1 :1). 210 mg (69% of theory) of i-methyl-S-trifluoromethyl-I H-pyrazole^-carboxylic acid (9- dichloromethylidene-benzonorbornene-5-yl)amide (compound A-1.4, m.p. 179-181 0C) was obtained.<\/p>\n

According to the analysis of related databases, 113100-53-1, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2008\/131901; (2008); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 113100-53-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[195,131],"tags":[126],"class_list":["post-5519","post","type-post","status-publish","format-standard","hentry","category-113100-53-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 113100-53-1 as follows. 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