{"id":5518,"date":"2021-07-23T03:40:41","date_gmt":"2021-07-22T19:40:41","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5518"},"modified":"2021-07-23T03:40:41","modified_gmt":"2021-07-22T19:40:41","slug":"sources-of-common-compounds-c6h9n3o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5518","title":{"rendered":"Sources of common compounds: C6H9N3O2"},"content":{"rendered":"

These common heterocyclic compound, 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1260243-04-6<\/a><\/p>\n

To a mixture of ethyl 5-amino- lH-pyrazole-4-carboxylate (150.00 g, 1.08 mmol) and ethyl (E)-3-ethoxyprop-2-enoate (292.16 g, 2.03 mol) in DMF (3.2 L) was added Cs2C03 (656.77 g, 2.02 mol) in one portion at 20 \u00b0C under N2. The mixture was stirred at 110 \u00b0C for 6 h. TLC (PE: EtOAc=l : 1) showed the reaction was completed. The mixture was cooled to 20 \u00b0C and filtered through a celite pad. The filter cake was washed with ethyl acetate (3X30 mL). The filtrate was added to H20 (2 L) and acidified with HOAc to pH=4. The resultant precipitate was filtered to afford A-1-7 (173.00 g, 834.98 mmol, 86.36percent yield) as a white solid: 1H NMR (400 MHz, DMSO-d6) delta 8.54 (d, 7=7.91 Hz, 1H), 8.12 (s, 1H), 6.13 (d, 7=7.91 Hz, 1H), 4.27 (q, 7=7.11 Hz, 2H), 1.28 (t, 7=7.09 Hz, 3H).<\/p>\n

The synthetic route of Ethyl 5-amino-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; TP THERAPEUTICS, INC.; CUI, Jingrong J.; LI, Yishan; ROGERS, Evan W.; ZHAI, Dayong; DENG, Wei; UNG, Jane; (170 pag.)WO2017\/4342; (2017); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of Ethyl 5-amino-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[213,131],"tags":[126],"class_list":["post-5518","post","type-post","status-publish","format-standard","hentry","category-1260243-04-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds:<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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