{"id":5488,"date":"2021-07-22T03:44:45","date_gmt":"2021-07-21T19:44:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5488"},"modified":"2021-07-22T03:44:45","modified_gmt":"2021-07-21T19:44:45","slug":"introduction-of-a-new-synthetic-route-about-1-methyl-1h-pyrazol-3-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5488","title":{"rendered":"Introduction of a new synthetic route about 1-Methyl-1H-pyrazol-3-amine"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1904-31-0, Safety of 1-Methyl-1H-pyrazol-3-amine<\/a><\/p>\n

To a mixture of 27 (160 mg, 0.45 mmol), 1-methyl-1H-pyrazol-3-amine (48 mg, 0.49 mmol), Pd2(dba)3 (38 mg, 0.024 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos, 27 mg, 0.047 mmol) in toluene (5 mL) was added Cs2CO3(220 mg, 0.68 mmol), and the mixture was stirred at 85 \u00b0C for 2 h under an argon gas atmosphere. After cooling at room temperature, the mixture was concentrated in vacuo. The residue was purifiedby silica gel column chromatography (0?30percent EtOAc in CHCl3) to give 30b (145 mg, 87percent) as an orange solid. 1H NMR (CDCl3) delta 3.78 (s, 3H), 5.41 (s, 2H), 5.91 (d, 1H, J = 2.2 Hz), 6.51 (dd, 1H, J = 9.5, 2.7 Hz), 7.21 (d, 1H, J = 2.2 Hz), 7.48 (d, 1H, J = 2.6 Hz), 7.54?7.59 (m, 1H), 7.62 (d, 1H, J = 8.5 Hz), 7.73?7.78 (m, 1H), 7.83?7.86 (m, 1H), 8.06 (d, 1H, J = 8.6 Hz), 8.18?8.23 (m, 2H), 10.02 (s, 1H); MS (ESI) m\/z 376 [M+H]+.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Article; Hamaguchi, Wataru; Masuda, Naoyuki; Isomura, Mai; Miyamoto, Satoshi; Kikuchi, Shigetoshi; Amano, Yasushi; Honbou, Kazuya; Mihara, Takuma; Watanabe, Toshihiro; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7612 – 7623;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[219,131],"tags":[145],"class_list":["post-5488","post","type-post","status-publish","format-standard","hentry","category-1904-31-0","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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