{"id":5486,"date":"2021-07-22T03:44:45","date_gmt":"2021-07-21T19:44:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5486"},"modified":"2021-07-22T03:44:45","modified_gmt":"2021-07-21T19:44:45","slug":"the-important-role-of-118430-73-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5486","title":{"rendered":"The important role of 118430-73-2"},"content":{"rendered":"

Related Products of 118430-73-2<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118430-73-2 as follows.<\/p>\n

To a suspension of 3 -tert-butyl-1 -methyl- lH-pyrazol-5 -amine(0.75g, 9.8mmol) and potassium carbonate (1.76 g, 12.7 mmol) in THF (20mL) at 0 C was added dropwise phenyl chloroformate (0.7 mL, 10.8 mmol). The mixture was stirred at rt for 16 h. The mixture was then filtered through celite and solvent was removed under reduced pressure. The crude residue was purified by silica gel flash chromatography, eluting with 0 % to 100% EtOAc in hexanes, to afford phenyl 3-tert- butyl-1 -methyl- lH-pyrazol-5-ylcarbamate (1.05 g, 39% yield). LCMS (ESI) m\/z 348 (M+H)+; 1H NMR (300 MHz, DMSO-d6) delta 10.11 (br s, 1H), 7.45-7.40 (m, 2H), 7.29- 7.21 (m, 3H), 6.04 (s, 1H), 3.58 (s, 3H), 1.20 (s, 9H).<\/p>\n

According to the analysis of related databases, 118430-73-2, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; AMBIT BIOSCIENCES CORPORATION; LIU, Gang; WO2011\/150198; (2011); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 118430-73-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[241,131],"tags":[126],"class_list":["post-5486","post","type-post","status-publish","format-standard","hentry","category-118430-73-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Related Products of 118430-73-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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