{"id":5467,"date":"2021-07-21T06:26:02","date_gmt":"2021-07-20T22:26:02","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5467"},"modified":"2021-07-21T06:26:02","modified_gmt":"2021-07-20T22:26:02","slug":"sources-of-common-compounds-118430-73-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5467","title":{"rendered":"Sources of common compounds: 118430-73-2"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 118430-73-2, name is 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H15N3<\/a><\/p>\n

Compound 3B-1 (1.00 g, 4.49 mmol, 1.0 eq), 5-tert-butyl-2-methyl-pyrazol-3-amine (1.38 g, 8.98 mmol, 2.0 eq), Pd2(dba)3 (82.3 mg, 89.8 umol, 0.02 eq), DavePhos (70.7 mg, 180 umol, 0.04 eq) and LiHMDS (1 M, 9.10 mL, 2.0 eq) were taken up into a microwave tube in dioxane (10 mL). The sealed tube was heated at 150 C for 30 min under microwave. TLC (petroleum ether: ethyl acetate = 1:1, Rf = 0.71), LCMS (ET15300-11-P1A, product RT = 0.972), LCMS (ET15300-11-P1B, product RT = 0.973) showed the starting material was consumed completely. The two reaction mixture were combined and concentrated in reduced pressure at 40 C. The residue was purified by silica gel chromatography (100-200 mesh silica gel), eluted with petroleum ether: ethyl acetate (80: 1~ 0: 1) to afford compound 3C-2 (1.00 g, 2.95 mmol, 32.8 %yield) as yellow solid. NMR: ET15300-11-P1A 400 MHz CDC1 delta 8.16 (d, J = 6.0 Hz, 1H), 7.90 (d, J = 8.4 Hz, 1H), 7.45 (d, J = 8.8 Hz, 1H), 7.01 (d, J = 6.0 Hz, 1H), 6.08 (s, 1H), 3.72 (s, 3H), 2.55 (s, 3H), 1.34 (s, 9H).<\/p>\n

According to the analysis of related databases, 118430-73-2, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; LUTRIS PHARMA LTD.; SHELACH, Noa; (76 pag.)WO2019\/26065; (2019); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 118430-73-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[241,131],"tags":[126],"class_list":["post-5467","post","type-post","status-publish","format-standard","hentry","category-118430-73-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds:<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 118430-73-2, name is 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H15N3\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5467\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds:\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 118430-73-2, name is 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. 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