{"id":5466,"date":"2021-07-21T06:26:02","date_gmt":"2021-07-20T22:26:02","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5466"},"modified":"2021-07-21T06:26:02","modified_gmt":"2021-07-20T22:26:02","slug":"some-scientific-research-about-135-trimethyl-1h-pyrazol-4-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5466","title":{"rendered":"Some scientific research about 1,3,5-Trimethyl-1H-pyrazol-4-amine"},"content":{"rendered":"

Some common heterocyclic compound, 28466-21-9, name is 1,3,5-Trimethyl-1H-pyrazol-4-amine, molecular formula is C6H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 28466-21-9<\/a><\/p>\n

Step A (1,3,5-trimethyl-pyrazol-4-yl)-isothiocyanate A mixture of 4-amino-1,3,5-trimethylpyrazole (1.32 g, 10.6 mmol) in 50 mL each of CHCl3 and saturated aqueous NaHCO3 was treated dropwise with thiophosgene (0.812 mL, 10.6 mmol) and stirred vigorously for 20 minutes. The layers were separated and the organic phase was washed with brine. After drying (Na2 SO4), the solvent was evaporated in vacuo to provide the title compound (1.8 g, brown oil) suitable for use directly in the next step. NMR (DMSO-d6, 300 MHz): 2.12 (s, 3H, ArCH3), 2.22 (s, 3H, ArCH3), 3.63 (s, 3H, NHCH3).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 28466-21-9, its application will become more common.<\/p>\n

Reference:
Patent; American Home Products Corporation; US6011053; (2000); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 28466-21-9, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[624,131],"tags":[126],"class_list":["post-5466","post","type-post","status-publish","format-standard","hentry","category-28466-21-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome scientific research about<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 28466-21-9, name is 1,3,5-Trimethyl-1H-pyrazol-4-amine, molecular formula is C6H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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