{"id":5452,"date":"2021-07-20T06:25:03","date_gmt":"2021-07-19T22:25:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5452"},"modified":"2021-07-20T06:25:03","modified_gmt":"2021-07-19T22:25:03","slug":"extracurricular-laboratory-synthetic-route-of-85290-80-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5452","title":{"rendered":"Extracurricular laboratory: Synthetic route of 85290-80-8"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 85290-80-8, name is Ethyl 1-methyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 85290-80-8, Application In Synthesis of Ethyl 1-methyl-1H-pyrazole-4-carboxylate<\/a><\/p>\n

Step 2 Preparation of 1-methyl-1H-pyrazole-4-carboxylic acid A solution of 1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (300 mg, 1.95 mmol) in ethanol cooled to 0 C. was treated with a 1N aqueous sodium hydroxide solution. The reaction was then warmed to 25 C. and was stirred at 25 C. for 18 h. At this time, the reaction was concentrated in vacuo and acidified to pH=2 with a 1N aqueous hydrochloric acid solution. This solution was extracted with ethyl acetate (3*50 mL). The organics were washed with a saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered, and dried in vacuo to afford 1-methyl-1H-pyrazole-4-carboxylic acid (193 mg, 78.5%) as a white solid: LR-MS for C5H6N2O2 (M-H)+ at m\/z=125.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-methyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; Dunten, Peter W.; Foley, Louise H.; Huby, Nicholas J.S.; Pietranico-Cole, Sherrie L.; Yun, Weiya; US2004\/14766; (2004); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-methyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[302,131],"tags":[126],"class_list":["post-5452","post","type-post","status-publish","format-standard","hentry","category-85290-80-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 85290-80-8, name is Ethyl 1-methyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 85290-80-8, Application In Synthesis of Ethyl 1-methyl-1H-pyrazole-4-carboxylate\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5452\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extracurricular laboratory: Synthetic route of\" \/>\n<meta property=\"og:description\" content=\"Adding a certain compound to certain chemical reactions, such as: 85290-80-8, name is Ethyl 1-methyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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