{"id":5439,"date":"2021-07-20T06:24:13","date_gmt":"2021-07-19T22:24:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5439"},"modified":"2021-07-20T06:24:13","modified_gmt":"2021-07-19T22:24:13","slug":"analyzing-the-synthesis-route-of-ethyl-1h-pyrazole-3-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5439","title":{"rendered":"Analyzing the synthesis route of Ethyl 1H-pyrazole-3-carboxylate"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5932-27-4, Product Details of 5932-27-4<\/a><\/p>\n

To a solution of K2CO3 (94 mg, 0.66mmol) in DMF (8 mL) was added ethyl 1H-pyrazole-3-carboxylate (158 mg, 1.12 mmol). The mixture was stirred at 20 oC for 0.5 h under N2. Then to mixture was added a solution of A33 (100 mg, 0.22 mmol) in DMF (4 mL), and stirred at 20oC for 3 h. The mixture was diluted with EtOAc (50 mL), washed with brine (50mL*3) and the organic layer was dried over anhydrous Na2SO4, and then concentrated to give crude product. It was purification by column chromatography (petroleum ether: ethyl acetate = 4:1) to give the 40 (45 mg) as a yellow solid. 1H NMR (40): (400 MHz, CDCl3) delta 7.44 (d, J = 2 Hz, 1H), 6.87 (d, J = 2.4 Hz, 1H), 5.30 (s, 3H), 4.40 (dd, J =7.6 Hz, J =14.8 Hz, 2H), 3.96-3.91 (m, 1H), 3.60-3.53 (m, 1H), 3.47-3.38 (m , 2H), 2.60-2.52 (m, 1H), 2.21-2.11 (m, 1H), 2.07-2.00 (m, 1H), 1.90 -1.61 (m, 6H), 1.52-1.15 (m, 17H), 1.03 -0.92 (m, 4H), 0.82-0.72 (m, 1H), 0.66 (s, 3H)<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; SAGE THERAPEUTICS, INC.; MARTINEZ BOTELLA, Gabriel; SALITURO, Francesco, G.; ROBICHAUD, Albert, Jean; HARRISON, Boyd, L.; (275 pag.)WO2016\/61527; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[170,131],"tags":[126],"class_list":["post-5439","post","type-post","status-publish","format-standard","hentry","category-5932-27-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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