{"id":5436,"date":"2021-07-20T06:24:13","date_gmt":"2021-07-19T22:24:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5436"},"modified":"2021-07-20T06:24:13","modified_gmt":"2021-07-19T22:24:13","slug":"discovery-of-c11h5cl2f3n4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5436","title":{"rendered":"Discovery of C11H5Cl2F3N4"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 120068-79-3, Application In Synthesis of 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile<\/a><\/p>\n

In a three-necked flask equipped with a dropping funnel, a stirrer and a thermometer was added lmol of 5-amino-3-cyano-1-(2,6-dichloro-4- (trifluoromethyl) phenyl) -pyrazole (II), 1.5piomicron1 sodium trifluoromethylsulfinate, 800ml of toluene and 0.08 mol (III) ionic liquid,After stirring for 5 min, the mixture was cooled to -2 C with stirring under ice-cooling. The mixture was stirred under stirringIn the above reactor, a solution of 1.2 mol of phosphorus trichloride in 80 ml of toluene was slowly added dropwise, stirred and heated to 50 C for 5 h,The reaction was quenched with ice water, extracted with methylene chloride, the organic phase was kept and washed once with saturated sodium bicarbonate, washed with brine. 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile(0.965mol, ? 96% yield) (I),, the purity was 97.7%; further recrystallization was carried out using toluene, and the yield was 90%To give a purity of ? 99% (yield ? 94%)<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; Dongguan City, Green Wheat Field Digital Technology Co.,Ltd; Liu, Lirong; (6 pag.)CN105541718; (2016); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[166,131],"tags":[167],"class_list":["post-5436","post","type-post","status-publish","format-standard","hentry","category-120068-79-3","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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