{"id":5423,"date":"2021-07-19T03:52:52","date_gmt":"2021-07-18T19:52:52","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5423"},"modified":"2021-07-19T03:52:52","modified_gmt":"2021-07-18T19:52:52","slug":"simple-exploration-of-c5h6n2o","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5423","title":{"rendered":"Simple exploration of C5H6N2O"},"content":{"rendered":"

Synthetic Route of 25016-11-9<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25016-11-9 as follows.<\/p>\n

To a solution of l-methyl-IH-pyrazole-4-carbaldehyde (104a)(4.8 g, 43.6 mmol) in tetrahydrofuran (80 mL) was cooled to 0 C was added dropwise (3- (bis(trimethylsilyl)amino)phenyl)rnagnesium chloride (49c) (49.0 mL, 49.0 mmol) and stirred at 0 C for 2 h. The reaction was quenched with saturated aqueous NH4CI (1 20 mL)and extracted with ethyl acetate (2 x 120 rnL). The combined organic extracts were washed with brine (100 mL), dried over MgSO4 followed by filtration and concentration. The residue was dissolved in ether (200 mL), treated with 4 N HCI in I ,4-dioxane (24 mL) and stirred at room temperature for 2 h. The solid obtained was collected by filtration washedwith ether, dried under vacuum to give (3-aminophenyl)(l-methyl-IH-pyrazol-4- yl)methanol (104b) (6.01 g, 68%) as an off-white solid; ?H NMR (300 MHz, DMSO-d(,) 8 7.47 (s, 111), 7.46- 7.20 (in, 5H), 5.69 (s, I H), 3.76 (s, 3H); MS (ES+) 204.1 (M+1).<\/p>\n

According to the analysis of related databases, 25016-11-9, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.; WU, Minwan; CHINTAREDDY, Venkat, R.; KUMAR, V., Satish; ZHANG, Weihe; WO2015\/134998; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 25016-11-9, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[151,131],"tags":[126],"class_list":["post-5423","post","type-post","status-publish","format-standard","hentry","category-25016-11-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 25016-11-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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