{"id":5400,"date":"2021-07-19T03:52:02","date_gmt":"2021-07-18T19:52:02","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5400"},"modified":"2021-07-19T03:52:02","modified_gmt":"2021-07-18T19:52:02","slug":"share-a-compound-2458-26-6-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5400","title":{"rendered":"Share a compound : 2458-26-6"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 2458-26-6, name is 3-Phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2458-26-6, name: 3-Phenyl-1H-pyrazole<\/a><\/p>\n

Methyl 3-(3-phenyl- 1 H -pyrazol- 1 -yl)butanoate 3-Phenyl-1 H-pyrazole (250 mg, 1 .73 mmol), methyl crotonate (275 muIota, 2.60 mmol) and DBU (130 muIota, 0.87 mmol) were combined in acetonitrile (3.5 ml), under nitrogen. The reaction was stirred at 50 C for 18 h and by TLC the reaction was complete. All of the volatiles were removed in vacuo and the crude material was purified by column chromatography, eluting 15-25% ethyl acetate\/petroleum spirits. The title compound was obtained as a colourless oil [32] mg, 76%). HPLC – rt 7.48 min > 98% purity at 254 nm; LRMS [M+H]+ 245.2 m\/z; HRMS [M+H]+ 245.1285 m\/z, found 245.1284 m\/z; 1 H NMR (400 MHz, DMSO) delta 7.87 – 7.70 (m, 3H), 7.44 – 7.33 (m, 2H), 7.33 – 7.19 (m, 1 H), 6.66 (d, J = 2.3 Hz, 1 H), 4.93 – 4.62 (m, 1 H), 3.56 (s, 3H), 2.93 (ddd, J= 22.0, 16.0, 7.0 Hz, 2H), 1 .48 (d, J = 6.8 Hz, 3H); 13C NMR (101 MHz, DMSO) delta 170.8, 149.7, 133.5, 130.3, 128.6 (2C), 127.3, 125.0 (2C), 102.2, 54.0, 51 .5, 40.5, 20.9.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; MONASH UNIVERSITY; THE UNIVERSITY OF WESTERN AUSTRALIA; BAELL, Jonathan; PIGGOTT, Matthew; RUSSELL, Stephanie; TOYNTON, Arthur; RAHMANI, Raphael; FERRINS, Lori; NGUYEN, Nghi; (178 pag.)WO2015\/172196; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[164,131],"tags":[126],"class_list":["post-5400","post","type-post","status-publish","format-standard","hentry","category-2458-26-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound :<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 2458-26-6, name is 3-Phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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