{"id":5376,"date":"2021-07-16T03:27:16","date_gmt":"2021-07-15T19:27:16","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5376"},"modified":"2021-07-16T03:27:16","modified_gmt":"2021-07-15T19:27:16","slug":"the-origin-of-a-common-compound-about-52222-73-8-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5376","title":{"rendered":"The origin of a common compound about 52222-73-8"},"content":{"rendered":"

Synthetic Route of 52222-73-8<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52222-73-8 name is 4-(Trifluoromethyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

[00564] Intermediate 57a: ethyl 2-[4-(trifluoromethyl)pyrazol-1 -yI]acetate [00565] 4-(Trifluoromethyl)-1 H-pyrazole (100mg, 0.73mmol) and potassium carbonate (305mg, 2.2Ommol) were left to stir in MeCN (2mL) for 30 minutes at room temperature before the addition of ethyl bromoacetate (0.l2mL, 1.lOmmol). The reaction mixture was then heated to 60C and left to stir at this temperature for 2 hours. The reaction was allowed to cool to room temperature andquenched by the addition of water (2OmL) and this solution was extracted with EtOAc (3 x 2OmL).The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo to giveethyl 2-[4-(trifluoromethyl)pyrazol-1-yl]acetate (1 60mg, 0.72mmol, 100% yield) as a yellow oil.1H NMR (CDCI3,400MHZ) O\/ppm: 7.82 (1H, 5), 7.77 (1H, 5), 4.95 (2H, 5), 4.29 (2H, q, J= 7.1Hz),1.32 (3H, t, J= 7.1Hz).MS Method 2: RT: 1.54 mi mlz 222.9 [M+H]<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Trifluoromethyl)-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; REDX PHARMA PLC; ARMER, Richard; BELFIELD, Andrew; BINGHAM, Matilda; JOHNSON, Alice; MARGATHE, Jean-Francois; AVERY, Craig; HUGHES, Shaun; MORRISON, Angus; (278 pag.)WO2016\/51193; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Trifluoromethyl)-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[137,131],"tags":[126],"class_list":["post-5376","post","type-post","status-publish","format-standard","hentry","category-52222-73-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe origin of a common compound about<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 52222-73-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52222-73-8 name is 4-(Trifluoromethyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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