{"id":5374,"date":"2021-07-16T03:27:16","date_gmt":"2021-07-15T19:27:16","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5374"},"modified":"2021-07-16T03:27:16","modified_gmt":"2021-07-15T19:27:16","slug":"discovery-of-14-dimethylpyrazole-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5374","title":{"rendered":"Discovery of 1,4-Dimethylpyrazole"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1072-68-0, name is 1,4-Dimethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C5H8N2<\/a><\/p>\n

1,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole A solution of 1,4-dimethyl-1H-pyrazole (480.0 mg, 4.993 mol) in tetrahydrofuran (20 mL, 300 mmol) at 0 C. was added 1.6 M n-butyllithium in hexane (4.7 mL, 7.5 mmol). The solution was stirred at room temperature for 1 h and then cooled to -78 C. To the solution was added 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.63 mL, 7.99 mmol). The reaction mixture was stirred at -78 C. for 0.5 h, then warmed up to 0 C. (taking 0.5 h). The reaction was quenched with brine and extracted with EtOAc (3*). The combined organic phases were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The residue was purified by combi-flash chromatography and eluted with EtOAc\/hexane (0-60%). The purification gave 142 mg of product as white solid.<\/p>\n

The synthetic route of 1072-68-0 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Incyte Corporation; Huang, Taisheng; Feng, Hao; Kong, Lingquan; Wang, Anlai; Ye, Hai Fen; US2013\/96144; (2013); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1072-68-0 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[179,131],"tags":[145],"class_list":["post-5374","post","type-post","status-publish","format-standard","hentry","category-1072-68-0","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1072-68-0, name is 1,4-Dimethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 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