{"id":5368,"date":"2021-07-16T03:27:16","date_gmt":"2021-07-15T19:27:16","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5368"},"modified":"2021-07-16T03:27:16","modified_gmt":"2021-07-15T19:27:16","slug":"new-learning-discoveries-about-6076-14-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5368","title":{"rendered":"New learning discoveries about 6076-14-8"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 6076-14-8, name is Ethyl 4-bromo-5-methyl-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6076-14-8, Formula: C7H9BrN2O2<\/a><\/p>\n

Reference Example 24; Ethyl 4-bromo-1-[4-(tert-butoxycarbonyl)benzyl]-5-methyl-1H-pyrazole-3-carboxylate Ethyl 4-bromo-5-methyl-1H-pyrazole-3-carboxylate (25.5 g) was dissolved in DMF (500 mL), ice-cooled, and potassium tert-butoxide (14.7 g) was added. The reaction mixture was stirred for 10 min, and a solution (14.7 g\/50 mL) of tert-butyl 4-(bromomethyl)benzoate in DMF was added dropwise slowly. The reaction mixture was stirred at 0 C. for 1.5 hr, poured into saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated. The obtained residue was purified by column chromatography (hexane-ethyl acetate) to give two kinds of positional isomers. A high polar compound was washed with diisopropyl ether-hexane to give the title compound (11.6 g) as colorless crystals.1H-NMR (CDCl3) delta: 1.43 (3H, t), 1.58 (9H, s), 2.16 (3H, s), 4.45 (2H, q), 5.45 (2H, s), 7.13 (2H, d), 7.95 (2H, d).<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009\/270359; (2009); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[529,131],"tags":[127],"class_list":["post-5368","post","type-post","status-publish","format-standard","hentry","category-6076-14-8","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nNew learning discoveries about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 6076-14-8, name is Ethyl 4-bromo-5-methyl-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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