{"id":5344,"date":"2021-07-14T03:25:56","date_gmt":"2021-07-13T19:25:56","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5344"},"modified":"2021-07-14T03:25:56","modified_gmt":"2021-07-13T19:25:56","slug":"some-scientific-research-about-c4h5cln2o2s","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5344","title":{"rendered":"Some scientific research about C4H5ClN2O2S"},"content":{"rendered":"

Reference of 288148-34-5<\/a>, These common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a solution of 4-(5-fluoro-lH-indol-3-yl)-iV’-(4-piperazin-l-ylphenyl)pyrimidin-2-amine (20 mg, 0.051 mmol) in dimethylforamide (1 mL), were added l-methyl-lH-pyrazole-4-sulfonyl chloride (9.3 mg, 0.051 mmol), triethylamine (31.3 mg, 0.309 mmol), and 4-dimethylamino pyridine (cat.). The solution was allowed to stir for 12 hr. After completion of the reaction, the reaction mixture was concentrated and purified by reverse phase chromatography (100% H2O to 100% MeCN) to afford ^(S-fluoro-lH-indol-S-y^-N^-f^tCl-methyl-lH-pyrazoM- yl)sulfonyl]piperazin-l-yl}phenyl)pyrimidin-2-amine as a mono trifluoroacetic acid salt. LRMS m\/z (M+H) Calcd: 533.2, found: 533.1.<\/p>\n

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; MERCK & CO., INC.; WO2007\/149427; (2007); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[224,131],"tags":[126],"class_list":["post-5344","post","type-post","status-publish","format-standard","hentry","category-288148-34-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome scientific research about<\/title>\n<meta name=\"description\" content=\"Reference of 288148-34-5, These common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=5344\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Some scientific research about\" \/>\n<meta property=\"og:description\" content=\"Reference of 288148-34-5, These common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=5344\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-07-13T19:25:56+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=5344\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=5344\",\"name\":\"Some scientific research about\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-07-13T19:25:56+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 288148-34-5, These common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=5344#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=5344\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=5344#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Some scientific research about C4H5ClN2O2S\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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