{"id":5319,"date":"2021-07-13T03:47:21","date_gmt":"2021-07-12T19:47:21","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5319"},"modified":"2021-07-13T03:47:21","modified_gmt":"2021-07-12T19:47:21","slug":"introduction-of-a-new-synthetic-route-about-67-51-6-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5319","title":{"rendered":"Introduction of a new synthetic route about 67-51-6"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H8N2<\/a><\/p>\n

(1000mg, 10.40mmol) and KOH (1675mg, 10.40mmol) was dissolved in DMSO, and the resulting heterogeneous solution was stirred at 80 1.5h, then cooled to room temperature. Then, added over 15 minutes a solution of 6M DMSO (876mg, 15.61mmol), and the reaction mixture was stirred for 2.5 hours. TLC observation to monitor whether the reaction is complete. The reaction was dissolved in water, the aqueous phase with CHCl3 extraction. The combined organic layers were washed with 100ml of water, dried over anhydrous Na2SO4, dried and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel, eluting with 20% ethyl acetate in petroleum ether. To give a yellow oil.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 67-51-6.<\/p>\n

Reference:
Patent; Southern Medical University; Cheng Kui; Xu Yao; (20 pag.)CN109867662; (2019); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 67-51-6.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[249,131],"tags":[145],"class_list":["post-5319","post","type-post","status-publish","format-standard","hentry","category-67-51-6","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, This compound has unique chemical properties. 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