{"id":5301,"date":"2021-07-12T03:18:25","date_gmt":"2021-07-11T19:18:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5301"},"modified":"2021-07-12T03:18:25","modified_gmt":"2021-07-11T19:18:25","slug":"sources-of-common-compounds-c4h3f3n2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5301","title":{"rendered":"Sources of common compounds: C4H3F3N2"},"content":{"rendered":"<p>Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., <a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Formula: C4H3F3N2<\/a><\/p>\n<p>Step 1: Into a 50 mL round bottom flask were added 3-(trifluoromethyl)-1H-pyrrazole (5.0 g, 33 mmol), sulfuric acid (25 mL) and nitration mixture (sulfuric acid and fuming nitric acid, 25 mL\/ 25 mL) and the reaction was stirred at room temperature for 16 h. The reaction mixture was diluted with ethyl acetate (100 mL), washed with water and saturated sodium bicarbonatesolution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure.The residue was purified by flash column chromatography eluting with ethyl acetate inpetroleum ether (20-30%) to furnish 4-nitro-3-(trifluoromethyl)-1H-pyrazole as a solid. ?HNMR(CDC13, 400 MHz): 11.66 (brs, 1H), 8.47 (s, 1H). MS calc?d [M-Hj 180.0, found180.0.<\/p>\n<p>Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand  reaction routes of 20154-03-4.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1002\/cmdc.201600276\">Patent; MERCK SHARP &amp; DOHME CORP.; LIM, Jongwon; ALTMAN, Michael, D.; BRUBAKER, Jason, D.; GIBEAU, Craig, R.; (187 pag.)WO2016\/144846; (2016); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand  reaction routes of 20154-03-4.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,131],"tags":[126],"class_list":["post-5301","post","type-post","status-publish","format-standard","hentry","category-20154-03-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Sources of common compounds:<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C4H3F3N2\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5301\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds:\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. 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The synthetic route is as follows., Formula: C4H3F3N2","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=5301","og_locale":"en_US","og_type":"article","og_title":"Sources of common compounds:","og_description":"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. 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