{"id":5297,"date":"2021-07-12T03:18:25","date_gmt":"2021-07-11T19:18:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5297"},"modified":"2021-07-12T03:18:25","modified_gmt":"2021-07-11T19:18:25","slug":"discovery-of-35-dimethyl-4-iodopyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5297","title":{"rendered":"Discovery of 3,5-Dimethyl-4-iodopyrazole"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2033-45-6, Product Details of 2033-45-6<\/a><\/p>\n

In a 50 ml reaction vessel under argon, a solution of crude 4-iodo-3,5-dimethyl-1 H- pyrazole x52 (1.15 g, 5.2 mmol) in 25 ml of dry CH2CI2 is added to 4- methylbenzenesulfonyl chloride (1.18 g, 6.2 mmol). Pyridine (0.42 ml, 5.2 mmol) is added EPO and the mixture is stirred for 16 h at room temperature. The organic phase is washed with water, dried over MgSOphi filtered and concentrated. The residue is purified by column chromatography on silicagel (Ch^C^\/hexane: 70\/30 (v\/v)) to afford 4-iodo-3,5-dimethyl-1- [(4-methylphenyl)sulfonyl]-1H-pyrazole x53 (1.44 g).Yield : 74 %.LC-MS (MH+): 377.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-iodopyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; UCB S.A.; WO2006\/128692; (2006); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-iodopyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[316,131],"tags":[127],"class_list":["post-5297","post","type-post","status-publish","format-standard","hentry","category-2033-45-6","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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