{"id":5269,"date":"2021-07-09T03:42:35","date_gmt":"2021-07-08T19:42:35","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5269"},"modified":"2021-07-09T03:42:35","modified_gmt":"2021-07-08T19:42:35","slug":"continuously-updated-synthesis-method-about-27258-32-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5269","title":{"rendered":"Continuously updated synthesis method about 27258-32-8"},"content":{"rendered":"

27258-32-8, name is 1-Methyl-1H-pyrazole-3-carbaldehyde, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C5H6N2O<\/a><\/p>\n

[00346] 55A. 3-((2-(4-bromophenyl)hydrazono)methyl)-l-methyl-lH-pyrazole: To a solution of (4-bromophenyl)hydrazine hydrochloride (1 150 mg, 5.04 mmol) and 1- methyl-lH-pyrazole-3-carbaldehyde (580 mg, 5.00 mmol) in DMF (5.1 mL) was added triethylamine (0.84 mL, 6.00 mmol). The mixture was stirred at rt under argon for 21 h, water (9 mL) was added and stirring was continued for 1 h. The solid that resulted was filtered, rinsed with water (5 mL) and dissolved in CH2C12 (120 mL). The CH2C12 solution was dried (Na2S04) and concentrated to provide 55A (1400 mg, 5.02 mmol, 100 percent yield) as a yellowish solid: lH NMR (400MHz, CDC13) d 7.76 (s, 1H), 7.63 (s, 1H), 7.34 (m, 3H), 6.97 (d, J= 8.8 Hz, 2H), 3.91 (s, 3H).<\/p>\n

The synthetic route of 27258-32-8 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HERNANDEZ, Andres S.; ELLSWORTH, Bruce A.; EWING, William R.; CHEN, Bin; WO2014\/78608; (2014); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 27258-32-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[417,131],"tags":[126],"class_list":["post-5269","post","type-post","status-publish","format-standard","hentry","category-27258-32-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"27258-32-8, name is 1-Methyl-1H-pyrazole-3-carbaldehyde, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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