{"id":5268,"date":"2021-07-09T03:42:35","date_gmt":"2021-07-08T19:42:35","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5268"},"modified":"2021-07-09T03:42:35","modified_gmt":"2021-07-08T19:42:35","slug":"some-tips-on-4-bromo-35-dimethylpyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5268","title":{"rendered":"Some tips on 4-Bromo-3,5-dimethylpyrazole"},"content":{"rendered":"

3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 4-Bromo-3,5-dimethylpyrazole<\/a><\/p>\n

17.63 g (0.101 mol) of the above intermediate was dissolved in 300 mL of carbon tetrachloride,19.58 g (0.11 mol) of NBS and 0.1 g of benzoyl peroxide were added and heated under reflux for 0.5 h.Stop the reaction, filter after cooling. The filtrate was concentrated and the resulting residue was poured into water and extracted with dichloromethane.The extracted organic phase was washed with saturated brine, dried over anhydrous sodium sulfate,The resulting residue was purified by silica gel column chromatography (silica gel 100-200 mesh, eluent petroleum ether: ethyl acetate = 20: 1)To give 21.2 g of product as a yellow liquid in 84.3percent yield.<\/p>\n

The synthetic route of 3398-16-1 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Chinese Academy Of Agricultural Sciences Plant Protection Institute; Mei Xiangdong; Dong Mengya; Ning Jun; Zhe Dongmei; Zhang Tao; Zhang Lanxiang; Si Weijie; (13 pag.)CN104610249; (2017); B;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 3398-16-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[250,131],"tags":[126],"class_list":["post-5268","post","type-post","status-publish","format-standard","hentry","category-3398-16-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome tips on<\/title>\n<meta name=\"description\" content=\"3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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