{"id":5179,"date":"2021-07-06T04:06:03","date_gmt":"2021-07-05T20:06:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5179"},"modified":"2021-07-06T04:06:03","modified_gmt":"2021-07-05T20:06:03","slug":"sources-of-common-compounds-c5h7n3o2-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5179","title":{"rendered":"Sources of common compounds: C5H7N3O2"},"content":{"rendered":"<p>632365-54-9, name is Methyl 5-amino-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. <a href=\"https:\/\/www.ambeed.com\/products\/632365-54-9.html\">Product Details of 632365-54-9<\/a><\/p>\n<p>5-Amino-3-pyrazolcarboxylic acid methyl ester (16.91 g, 119.8 mmol) is dissolved in ethanol (2.4 L) and hydrochloric acid (37%, 12.5 mL, 150 mmol) is added. Then, a solution of 2-bromo-malonealdehyde (18.9 g, 125.2 mmol) is dissolved in ethanol (1.4 L) and is quickly added in a drop wise manner at RT. After 30 min, a precipitation is observed; after 6 hours the precipitate is removed and washed with 50 ml ethanol and thereafter with 50 ml diethyl ether. Here, 4.19 g of the clean product are isolated. After evaporation of the filtrate and crystallisation, additional 1.43 g product are obtained to yield 6-Bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid methyl ester (5.62 g, 18.3% d. Th.). In case of a smaller scale reaction with only 1 g of the starting amine 5-amino-3-pyrazolcarboxylic acid methyl ester, the yield is much better e.g. 68%.<\/p>\n<p>The synthetic route of 632365-54-9 has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=US2008032998&#038;F=0\">Patent; MERZ PHARMA GMBH &amp; CO. KGAA; US2008\/32998; (2008); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 632365-54-9 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[303,131],"tags":[126],"class_list":["post-5179","post","type-post","status-publish","format-standard","hentry","category-632365-54-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Sources of common compounds:<\/title>\n<meta name=\"description\" content=\"632365-54-9, name is Methyl 5-amino-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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