{"id":5148,"date":"2021-07-05T03:13:38","date_gmt":"2021-07-04T19:13:38","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5148"},"modified":"2021-07-05T03:13:38","modified_gmt":"2021-07-04T19:13:38","slug":"share-a-compound-c10h10n2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5148","title":{"rendered":"Share a compound : C10H10N2"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13808-62-3, name is 4-Methyl-3-phenyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C10H10N2<\/a><\/p>\n

Part A — alpha,4-Dimethyl-3-phenylpyrazole-1-acetic acid Sodium hydride (50.0 g., 57% in oil, 1.2 mole) was added over 20 minutes to a stirred solution of 4-methyl-3-phenylpyrazole (158 g., 1.0 mole) in THF (1.0 l.) maintained at 10-20 C. Ethyl 2-bromopropionate (235 g., 1.3 mole) was added and the solution stirred for 18 hours, after which time ethanol was added and the solvent was removed by evaporation at reduced pressure. The residue was treated at 90 C. with sodium hydroxide (100 g., 2.5 mole) in 800 ml. 60% aqueous methanol for 30 minutes. After cooling, the solution was extracted with ether (3 * 200 ml.), and the aqueous phase was acidified with concentrated hydrochloric acid to give 148 g. of crude alpha,4-dimethyl-3-phenylpyrazole-1-acetic acid, m.p. 151-162 C. Recrystallization from aqueous methanol gave 111 g. of product, m.p. 168-172 C. The analytical sample was recrystallized from ethyl acetate, m.p. 170-172 C. Analysis: Calc’d for C13 H14 N2 O2: C, 67.81; H, 6.13; N, 12.17. Found: C, 68.32; H, 6.14; N, 12.06.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13808-62-3.<\/p>\n

Reference:
Patent; The Upjohn Company; US4072498; (1978); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13808-62-3.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[530,131],"tags":[126],"class_list":["post-5148","post","type-post","status-publish","format-standard","hentry","category-13808-62-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound :<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13808-62-3, name is 4-Methyl-3-phenyl-1H-pyrazole, This compound has unique chemical properties. 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