{"id":5147,"date":"2021-07-05T03:12:45","date_gmt":"2021-07-04T19:12:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5147"},"modified":"2021-07-05T03:12:45","modified_gmt":"2021-07-04T19:12:45","slug":"continuously-updated-synthesis-method-about-methyl-1h-pyrazole-3-carboxylate-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5147","title":{"rendered":"Continuously updated synthesis method about Methyl 1H-pyrazole-3-carboxylate"},"content":{"rendered":"<p>In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15366-34-4 as follows. <a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">Recommanded Product: 15366-34-4<\/a><\/p>\n<p>A solution of methyl 1H-pyrazole-3-carboxylate (5 g) in dry acetonitrile was treated with cesium carbonate (32.3 g) and methyl iodide (6.45 g) and the mixture was stirred at rt for 2 h. The suspension was filtered and the volatiles were removed under reduced pressure. The residue was purified by chromatography (SiO2, Cy\/EtOAc) to yield the desired product (66% yield). LC-MS (Method 1): m\/z [M+H]+=141.2 (MW calc.=140.14); Rt=1.0 min.<\/p>\n<p>According to the analysis of related databases, 15366-34-4, the application of this compound in the production field has become more and more popular.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=US2014194443&#038;F=0\">Patent; Gruenenthal GmbH; Nordhoff, Sonja; Wachten, Sebastian; Kless, Achim; Voss, Felix; Ritter, Stefanie; US2014\/194443; (2014); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to the analysis of related databases, 15366-34-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[174,131],"tags":[126],"class_list":["post-5147","post","type-post","status-publish","format-standard","hentry","category-15366-34-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Continuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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