{"id":5146,"date":"2021-07-05T03:12:45","date_gmt":"2021-07-04T19:12:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5146"},"modified":"2021-07-05T03:12:45","modified_gmt":"2021-07-04T19:12:45","slug":"analyzing-the-synthesis-route-of-13-dimethyl-1h-pyrazol-5-ol","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5146","title":{"rendered":"Analyzing the synthesis route of 1,3-Dimethyl-1H-pyrazol-5-ol"},"content":{"rendered":"

Electric Literature of 5203-77-0<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

At room temperature, 1,3-dimethyl-1H-pyrazole-5-ol (1.12 g, 0.01 mol) and (2.02 g, 0.02 mol) triethylamine were sequentially dissolved in 20 ml of dichloromethane.The low temperature bath was cooled to 3 C. To the above mixture, 5-(methylsulfonyl)quinoline-8-carbonyl chloride (2.83 g, 0.0105 mol) was added dropwise at a drop rate of 1 drop \/ 30 seconds. After the dropwise addition, the mixture naturally rose to room temperature and reacted for 5 hours. .To the reaction mixture was added 10 ml of a saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with dichloromethane (3 * 15 ml). The organic layers were combined, Wash with water (1 * 15ml), saturated brine, and dry over anhydrous magnesium sulfate.The product was desolvated under reduced pressure to obtain 2.76 g of the product with a yield of 80%<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 1,3-Dimethyl-1H-pyrazol-5-ol. I believe this compound will play a more active role in future production and life.<\/p>\n

Reference:
Patent; Shandong Joint Pesticide Co., Ltd.; Tang Jianfeng; Chi Huiwei; Wu Jianting; Yuan Xue; Liu Ying; (52 pag.)CN110615781; (2019); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 1,3-Dimethyl-1H-pyrazol-5-ol. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[253,131],"tags":[126],"class_list":["post-5146","post","type-post","status-publish","format-standard","hentry","category-5203-77-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of<\/title>\n<meta name=\"description\" content=\"Electric Literature of 5203-77-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol, This compound has unique chemical properties. 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