{"id":5132,"date":"2021-07-05T03:12:45","date_gmt":"2021-07-04T19:12:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5132"},"modified":"2021-07-05T03:12:45","modified_gmt":"2021-07-04T19:12:45","slug":"simple-exploration-of-c6h8n2o2-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5132","title":{"rendered":"Simple exploration of C6H8N2O2"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31728-75-3, name is 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 31728-75-3<\/a><\/p>\n

To a 0C solution of 1 ,5-dimethyl-lH-pyrazole-4-carboxylic acid (1.0 g, 7.14 mmol) in DCM\/MeOH (7 mL each) was added 2M TMSCHN2 in hexane (4.28 mL, 8.56 mmol). The reaction mixture was stirred at 0C for 1 h, then was allowed to warm to RT and stirred at RT overnight, then was concentrated in vacuo. The crude product was chromatographed (80 g Si02; continuous gradient from 0% to 50% EtOAc in hexane over 20 min) to give the title compound (900 mg, 5.84 mmol, 82 % yield). LCMS, [M + H]+ = 155.2.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31728-75-3.<\/p>\n

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; CHENG, Peter Tai Wah; LI, Jun; SHI, Yan; WANG, Ying; ZHANG, Hao; KENNEDY, Lawrence J.; WALKER, Steven J.; REDDIGUNTA, Ramesh Babu; (138 pag.)WO2019\/126098; (2019); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31728-75-3.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[299,131],"tags":[126],"class_list":["post-5132","post","type-post","status-publish","format-standard","hentry","category-31728-75-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31728-75-3, name is 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. 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