{"id":5129,"date":"2021-07-05T03:12:45","date_gmt":"2021-07-04T19:12:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5129"},"modified":"2021-07-05T03:12:45","modified_gmt":"2021-07-04T19:12:45","slug":"extended-knowledge-of-5334-43-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5129","title":{"rendered":"Extended knowledge of 5334-43-0"},"content":{"rendered":"

These common heterocyclic compound, 5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile<\/a><\/p>\n

EXAMPLE 2 1-Phenyl-4-cyano-5-(phenylureido)-pyrazole STR107 9.0 g (80 mmol) of potassium tert-butylate and 8.7 ml (80 mmol) of phenyl isocyanate were added to a solution of 5.52 g (30 mmol) of 1-phenyl-4-cyano-5-aminopyrazole in 100 ml of toluene. The mixture was heated for 15 hours at 80 C. and then cooled, the insoluble constituents were separated off and the resulting solution was acidified with acetic acid, the product crystallizing out. Yield: 96%.<\/p>\n

The synthetic route of 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; BASF Aktiengesellschaft; US5486618; (1996); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[148,131],"tags":[126],"class_list":["post-5129","post","type-post","status-publish","format-standard","hentry","category-5334-43-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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