{"id":5128,"date":"2021-07-05T03:12:45","date_gmt":"2021-07-04T19:12:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5128"},"modified":"2021-07-05T03:12:45","modified_gmt":"2021-07-04T19:12:45","slug":"the-important-role-of-c8h13n3o-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5128","title":{"rendered":"The important role of C8H13N3O"},"content":{"rendered":"

Reference of 1190380-49-4<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

Compound 11.4 (70 mg, 0.20 mmol, 1.00 eq.) and 1-(oxan-4-yl)-1H-pyrazol-4-amine (52 mg, 0.31 mmol, 1.50 eq.) were dissolved in HCl in dioxane (0.2 mL, 4N) and n- BuOH (2 mL). The reaction was stirred for 6 h at 110 C. The solids were collected by filtration and dissolved in H20. The pH value of the solution was adjusted to 10 with Na2CC”3. Precipitated solids were collected by filtration to provide 45.3 mg (47%) of compound I-17 as an off-white solid. LC-MS (ESI, w\/z):[M+H+]+= 483; 1H NMR (300 MHz, DMSO-d6): delta 8.93 (s, 1H), 7.98 (s ,1H) , 7.50 (s, 1H), 6.85 (s, 1H), 4.44 (m, 4H) , 4.12 (m, 1H), 3.96 (m, 2H), 3.56 (t, 4H), 3.48 (m, 2H), 2.50 (m, 4H), 2.25 (m, 1H), 1.91-2.07 (m, H), 1.28-1.60 (m, 4H).<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine. I believe this compound will play a more active role in future production and life.<\/p>\n

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; BOYCE, Sarah; (135 pag.)WO2017\/4133; (2017); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[210,131],"tags":[126],"class_list":["post-5128","post","type-post","status-publish","format-standard","hentry","category-1190380-49-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Reference of 1190380-49-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound has unique chemical properties. 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