{"id":5098,"date":"2021-07-02T03:51:13","date_gmt":"2021-07-01T19:51:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5098"},"modified":"2021-07-02T03:51:13","modified_gmt":"2021-07-01T19:51:13","slug":"introduction-of-a-new-synthetic-route-about-1203705-55-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5098","title":{"rendered":"Introduction of a new synthetic route about 1203705-55-8"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1203705-55-8 as follows. Safety of 3-Bromo-1H-pyrazol-5-amine<\/a><\/p>\n

1-(1,3-dimethyl-1H-pyrazol-4-yl)-4,4,4-trifluoro-3-hydroxybut-2-en-1-one (Preparation 5, 1.7 g) and 3-bromo-1H-pyrazol-5-amine (Preparation 6, 1.18 g) in Acetic acid (52.61 mL) was heated at 120 C. in a sealed tube overnight. The reaction solution was cooled to room temperature, and poured into ice water (500 mL) resulting in a white precipitate. The precipitate was filtered and washed with copious amounts of water. The precipitate was then collected and dried in vacuo to afford the title compound as a white powder (1.9 g, 73.1%). [0524] 1HNMR (400 MHz, DMSO-d6) delta: 2.47 (s, 3H), 3.79, (s, 3H), 6.95, (s, 1H), 7.73, (s, 1H), 8.67, (s, 1H).<\/p>\n

According to the analysis of related databases, 1203705-55-8, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; Boivin, Roch; Carlson, Eric; Endo, Atsushi; Hansen, Hans; Hawkins, Lynn D.; Ishizaka, Sally; Mackey, Matthew; Narayan, Sridhar; Satoh, Takashi; Schiller, Shawn; US2013\/324547; (2013); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 1203705-55-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[138,131],"tags":[126],"class_list":["post-5098","post","type-post","status-publish","format-standard","hentry","category-1203705-55-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1203705-55-8 as follows. 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