{"id":5072,"date":"2021-07-01T03:36:31","date_gmt":"2021-06-30T19:36:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5072"},"modified":"2021-07-01T03:36:31","modified_gmt":"2021-06-30T19:36:31","slug":"introduction-of-a-new-synthetic-route-about-4-bromo-1-tert-butyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5072","title":{"rendered":"Introduction of a new synthetic route about 4-Bromo-1-(tert-butyl)-1H-pyrazole"},"content":{"rendered":"

70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 4-Bromo-1-(tert-butyl)-1H-pyrazole<\/a><\/p>\n

General procedure: Pd(dppf)Cl2 (1.45 g, 1.98 mmol) was added to a mixture of 4-bromo-1-(tert-pentyl)-1H-pyrazole (8.6 g, 39.61 mmol), Intermediate 4 (6.56 g, 47.53 mmol), K2CO3 (10.95 g, 79.22 mmol), dioxane (90 mL), and H2O (45 mL) at rt under N2. The mixture was degassed with 3 vacuum\/N2 cycles, heated at 80 C. for 4 h, cooled to rt, and then poured into H2O (100 mL). The precipitate was filtered off. The filtrate was diluted with ethyl acetate (200 mL) and H2O (100 mL). The layers were separated, and the aqueous layer was extracted with ethyl acetate (3\u00d7200 mL). The combined organic layers were washed with brine (100 mL), dried over Na2SO4, filtered, concentrated, and then purified by silica gel chromatography (CH2Cl2\/CH3OH=100\/1?30\/1) to give 2.7 g of an impure red solid. HCl in CH3OH (4M, 30 mL) was added. The solution was stirred at rt for 2 h, concentrated, diluted with ethyl acetate (15 mL), and then stirred overnight. The solids were filtered, washed with ethyl acetate (10 mL), and dried to give 4-(1-(tert-pentyl)-1H-pyrazol-4-yl) pyridin-2-amine hydrochloride (3.1 g). This material was dissolved in H2O (5 mL). Aqueous potassium carbonate (2 M, 8 mL) was added slowly until pH=9-10. The mixture was extracted with ethyl acetate (20 mL\u00d76). The combined organics were washed with brine (10 mL), dried over Na2SO4, filtered, and concentrated to give 4-(1-(tert-pentyl)-1H-pyrazol-4-yl) pyridin-2-amine (2.35 g, 90%) as an off white solid. 1H NMR (400 MHz, DMSO-d6): delta 8.24 (s, 1H), 7.84-7.83 (m, 2H), 6.75-6.73 (m, 1H), 6.60 (s, 1H), 5.74 (s, 2H), 1.87-1.81 (m, 2H), 1.52 (s, 6H), 0.62 (t, 3H); LCMS: 231.2 [M+H]+.<\/p>\n

The synthetic route of 70951-85-8 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Metacrine, Inc.; SMITH, Nicholas D.; GOVEK, Steven P.; DOUGLAS, Karensa L.; LAI, Andiliy G.; US2020\/102308; (2020); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 70951-85-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[341,131],"tags":[127],"class_list":["post-5072","post","type-post","status-publish","format-standard","hentry","category-70951-85-8","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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