{"id":5071,"date":"2021-07-01T03:36:31","date_gmt":"2021-06-30T19:36:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5071"},"modified":"2021-07-01T03:36:31","modified_gmt":"2021-06-30T19:36:31","slug":"the-important-role-of-c3h4n2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5071","title":{"rendered":"The important role of C3H4N2"},"content":{"rendered":"

These common heterocyclic compound, 288-13-1, name is 1H-Pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1H-Pyrazole<\/a><\/p>\n

General procedure: General procedure: iodobenzene (1.0mmol), pyrazole (1.5 mmol), LiOH (2.0 mmol), TBAB(0.2 mmol), active Cu (0.1 mmol) and 2 mL H2O were added to a 10 mL flask. The mixture was heated in an oil bath at 120?. When the reaction completed, the resulting mixture was cooled to room temperature and the product was extracted by ethyl acetate (10 mL\u00d73). The combine dextracts were washed by brine (15 mL) , dried over MgSO4 and evaporated under reduced pressure. Further purification by silica gel column chromatography (5:1 petroleum ether\/ethylacetate) give 1-phenyl-1H-pyrazole (2a, 0.126 g, 88%) as a Colorless liquid.<\/p>\n

The synthetic route of 1H-Pyrazole has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Article; Yang, Qichao; Wang, Yufang; Lin, Dong; Zhang, Mingjie; Tetrahedron Letters; vol. 54; 15; (2013); p. 1994 – 1997;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1H-Pyrazole has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[149,131],"tags":[145],"class_list":["post-5071","post","type-post","status-publish","format-standard","hentry","category-288-13-1","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 288-13-1, name is 1H-Pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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