{"id":5056,"date":"2021-06-30T03:17:03","date_gmt":"2021-06-29T19:17:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5056"},"modified":"2021-06-30T03:17:03","modified_gmt":"2021-06-29T19:17:03","slug":"application-of-4-bromo-1-methyl-3-trifluoromethyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5056","title":{"rendered":"Application of 4-Bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole"},"content":{"rendered":"

497832-99-2, name is 4-Bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 497832-99-2<\/a><\/p>\n

A mixture of 286 tert-butyldimethyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)silane (1.0 g, 3.0 mmol), 288 4-bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole (822 mg, 3.6 mmol), and Pd(dppf)Cl2 (110 mg, 0.15 mmol), in a mixture of 80 acetonitrile (12 mL) and a 1 M aqueous solution of 179 NaHCO3 (5.4 mL) was bubbled with N2 for 1 min and then heated in a microwave reactor to 130 C. for 15 min. After cooling to rt, a 1 M solution of 289 TBAF in 10 THF (3 mL, 3 mmol) was added and the mixture was stirred at rt for 5 h, then diluted with CH2Cl2 and washed with water, brine, dried (MgSO4) and evaporated. The residue was purified (FCC, SiO2, 10-60% EtOAc\/heptanes) to provide the 281 title compound (445 mg, 61% yield) as an off-white solid. 1H NMR (300 MHz, CDCl3) delta 7.45 (d, J=1.00 Hz, 1H), 7.28 (d, J=1.00 Hz, 2H), 6.88 (d, J=8.56 Hz, 2H), 5.16 (br s, 1H), 3.99 (s, 3H). [M+H]=243.2.<\/p>\n

The synthetic route of 497832-99-2 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Dart NeuroScience, LLC; Bookser, Brett; Botrous, Iriny; Branstetter, Bryan; Dyck, Brian; Weinhouse, Michael; US2019\/177327; (2019); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 497832-99-2 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[358,131],"tags":[127],"class_list":["post-5056","post","type-post","status-publish","format-standard","hentry","category-497832-99-2","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nApplication of<\/title>\n<meta name=\"description\" content=\"497832-99-2, name is 4-Bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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