{"id":5055,"date":"2021-06-30T03:17:03","date_gmt":"2021-06-29T19:17:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5055"},"modified":"2021-06-30T03:17:03","modified_gmt":"2021-06-29T19:17:03","slug":"new-downstream-synthetic-route-of-c7h11brn2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5055","title":{"rendered":"New downstream synthetic route of C7H11BrN2"},"content":{"rendered":"

Electric Literature of 70951-85-8<\/a>, The chemical industry reduces the impact on the environment during synthesis 70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.<\/p>\n

A mixture of 4-bromo-1-(1 ,1-dimethylethyl)-1 H-pyrazole (2.4g, 1 1.82mmol), 4.4.4′.4′.5.5.5′.5′-octamethyl-2,2′-bi-1 ,3,2-dioxaborolane (3.00g, 1 1.82mmol), potassium acetate (2.90g, 29.5mmol), tris(dibenzylideneacetone)dipalladium (0) (0.108g, 0.1 18mmol), 2-(dicyclohexylphosphino)-2′.4′,6′-triisopropylbiphenyl (0.225g, 0.473mmol) in 1 ,4-dioxane (30ml) was degassed with nitrogen. The reaction mixture was spilt into 2 microwave vials and heated at 1 10C in a microwave for 1 .5h. There was no starting material remaining so the reactions were filtered through a bond elut reservoir and the residue was washed with ethyl acetate. The filtrate was concentrated in vacuo to yield the crude product. This was dissolved in DCM and purified through silica (50g) eluting with 0-50% ethyl acetate in DCM gradient. Appropriate fractions were combined and concentrated in vacuo to yield the title compound as a beige solid (1.68g).LCMS (Method B): Rt = 1 .08min, MH+ = 250.8<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-(tert-butyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Francis Louis; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander George Steven; WILSON, David Matthew; WO2011\/134971; (2011); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-(tert-butyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[341,131],"tags":[127],"class_list":["post-5055","post","type-post","status-publish","format-standard","hentry","category-70951-85-8","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nNew downstream synthetic route of<\/title>\n<meta name=\"description\" content=\"Electric Literature of 70951-85-8, The chemical industry reduces the impact on the environment during synthesis 70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5055\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New downstream synthetic route of\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 70951-85-8, The chemical industry reduces the impact on the environment during synthesis 70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5055\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-29T19:17:03+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5055\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5055\",\"name\":\"New downstream synthetic route of\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-06-29T19:17:03+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Electric Literature of 70951-85-8, The chemical industry reduces the impact on the environment during synthesis 70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5055#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=5055\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5055#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New downstream synthetic route of C7H11BrN2\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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