{"id":5041,"date":"2021-06-30T03:16:15","date_gmt":"2021-06-29T19:16:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5041"},"modified":"2021-06-30T03:16:15","modified_gmt":"2021-06-29T19:16:15","slug":"application-of-92525-10-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5041","title":{"rendered":"Application of 92525-10-5"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., COA of Formula: C4H5IN2<\/a><\/p>\n

A degassed solution of 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpyridin-2(1H)-one (27 mg, 0.100 mmol), 3-iodo-1-methyl-1H-pyrazole (20 mg, 0.097 mmol), N1,N2-dimethylethane-1,2-diamine (5 mg, 0.049 mmol), copper iodide (4 mg, 0.020 mmol), and potassium phosphate (43 mg, 0.197 mmol) 2 mL of N-methylpyrrolidone was heated to 70 C. After allowing the reaction to stir overnight (17 h) at 70 C., the reaction was complete and allowed to cool to room temperature. The reaction was extracted 3X’s with EtOAc (3*5 mL) and 2X’s with NaHCO3 (3*10 mL). The crude organic layers were combined, dried over anhydrous Na2SO4 (s), filtered and then concentrated in vacuo. The crude mixture was then purified using the ISCO flash chromatography system using a 0-100% EtOAc\/100-0% Hexane gradient mixture. A second column was done on the impure product using a gradient of MeOH\/CHCl3 after which, the appropriate fractions were concentrated, to afford a yellow solid (17 mg, 52%). 1H NMR (DMSO) delta: 8.01 (s, 1H), 7.79 (d, J=6.0, 1H), 6.34 (d, J=6.0, 1H), 6.24 (m, 1H), 6.15 (d, J=7.0 Hz, 2H), 4.00 (br. S, 2H), 3.22 (s, 2H), 2.64 (t, j=5.3 Hz, 2H), 2.20 (s, 3H)<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n

Reference:
Patent; Allergan, Inc.; Wurster, Julie; Yee, Richard; Hull III, Clarence Eugene; Malone, Thomas C.; (39 pag.)US2016\/96832; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[172,131],"tags":[127],"class_list":["post-5041","post","type-post","status-publish","format-standard","hentry","category-92525-10-5","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nApplication of<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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